Directions from the Hotel Staff
From Lafayette--take Interstate 49 North to the Creswell Lane Exit #18. From Creswell Lane Exit, take Frontage Road...hotel is on the right.
From Alexandria--Take Inte
Our Hampton Inn Opelousas hotel features a new and upscale design and is located near many things to do in Louisiana’s third oldest city near the Atchafalaya River. We are located off Interstate 49 wi